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Microfluidic resistive pulse sensing See every particle.
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3 µL
Sample volume
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<5 min
Per run
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50–10000 nm
Detection range
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Trusted by
Instruments
Choose the right instrument for your lab
MRPS + single-particle fluorescence phenotyping in one measurement.
- Up to 4 simultaneous optical channels
- Up to 4 excitation wavelengths
- Configurable excitation & emission
- GMP/GAMP & 21 CFR ready
- 50–10000 nm detection range
Fast and accurate nanoparticle size and concentration using MRPS.
- Real-time size & concentration
- 3 µL sample volume
- Results in minutes
- 50–10000 nm detection range
Our first groundbreaking MRPS system.
- Proven MRPS platform
- Wide range of applications
- Faster than DLS or NTA
- Absolute concentration output
Watch and learn more about the power of our Technology
See how we make every particle count
Spectradyne Particle Analysis produces groundbreaking technology for nanoparticle research. Spectradyne's instruments use patented microfluidic cartridge technology to detect and measure every particle in your formulation. We have developed a unique implementation of microfluidic resistive pulse sensing (MRPS), which uses electrical sensing to measure the diameter of each particle as it passes through a nanoconstriction, providing real-time sizing and concentration information. With our MRPS technology combined with excitation and collections optics in our ARC Particle Analyzer, fluorescent subpopulations can simultaneously be accurately quantified along with accurate size and concentration.
Applications
Built for the samples that matter most
Head-to-head comparison
What sets Spectradyne apart?
F-MRPS combines two orthogonal measurement methods to deliver accuracy that optical techniques simply cannot match.
| Spectradyne F-MRPS |
DLS | NTA | nanoFCM |
|---|
View data table
| Category | Spectradyne F-MRPS | DLS | NTA | nanoFCM |
|---|---|---|---|---|
| Measurement Principle | Electrical and optical — a unique combination of two orthogonal methods | Optical — light scattering, ensemble average | Optical — light scattering, single-particle tracking | Optical — light scattering, single-particle |
| Ease of Use | Excellent — fast and easy, no calibration, cleaning, or reference measurements required | Moderate — reference measurements required | Moderate — cleaning between samples; significant sample assumptions required | Poor — time-consuming alignment procedures, reference and calibration samples, laborious cleaning procedures |
| Accuracy for Complex Samples | Excellent — accuracy is independent of refractive index, polydispersity, or sample heterogeneity | Poor — polydispersity and heterogeneity strongly affect accuracy | Poor — polydispersity and heterogeneity strongly affect limits of detection and accuracy | Poor — heterogeneous optical properties (e.g. refractive index) strongly impact accuracy |
Head-to-head comparison
Resolving what DLS and NTA cannot
Polydisperse polystyrene sample containing four populations at 52, 94, 122, and 150 nm. MRPS resolves every population with absolute concentration. NTA misses the smallest particles. DLS reports a single broadened peak with no concentration data.
NTA detection falls off as D⁶, causing smaller particles to be missed and creating a false peak in the reported distribution. DLS averages across all particles, dominated by the largest. MRPS measures each particle individually using electrical sensing.
View data table
| Method | 52 nm | 94 nm | 122 nm | 150 nm | Absolute concentration | Resolves polydisperse mixtures |
|---|---|---|---|---|---|---|
| MRPS (Spectradyne) | ✓ | ✓ | ✓ | ✓ | Yes | Yes — all four peaks resolved |
| NTA | ✗ | Partial | ✓ | ✓ | Relative only | No — false peak cutoff below ~90 nm |
| DLS | ✗ | ✗ | ✗ | ✗ | No | No — single broadened peak, D⁶ dominated |
See what our customers have to say
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